Daclizumab HYP shows efficacy in patients with relapsing–remitting MS
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چکیده
منابع مشابه
CD56bright natural killer cells and response to daclizumab HYP in relapsing-remitting MS
OBJECTIVE To assess the relationship between CD56(bright) natural killer (NK) cells and multiple sclerosis (MS) disease activity in patients with relapsing-remitting MS treated with daclizumab high-yield process (DAC HYP). METHODS Data were from patients enrolled in a 52-week randomized, double-blind, placebo-controlled study of DAC HYP and its extension study. Assessments included relationsh...
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Monoclonal antibodies are a promising new class of therapeutic agents that can be employed to target specific molecules of the immune system or any tissue. They are currently being tested in a number of clinical trials in autoimmune diseases such as multiple sclerosis (MS). One of these, the humanized monoclonal anti-CD25 antibody daclizumab (Zenapax), is directed against the interleukin-2 (IL-...
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OBJECTIVE The purpose of this study was to assess the potential immunosuppressive role of daclizumab, a humanized monoclonal antibody against the α chain of the interleukin 2 receptor, in vivo, by comparing immune responses to the 2013 seasonal influenza vaccination between patients with multiple sclerosis (MS) on long-term daclizumab therapy and controls. METHODS Previously defined subpopula...
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BACKGROUND Daclizumab, a humanized monoclonal antibody specific for the interleukin 2 receptor α chain, reduces clinical and magnetic resonance imaging disease activity in patients with adult-onset multiple sclerosis (MS) as monotherapy or add-on therapy with interferon. OBJECTIVE To report the use of daclizumab in pediatric-onset MS. DESIGN Case series. SETTING Two comprehensive pediatri...
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ژورنال
عنوان ژورنال: Nature Reviews Neurology
سال: 2013
ISSN: 1759-4758,1759-4766
DOI: 10.1038/nrneurol.2013.79